Hi Caroline. Professor Studd is quite unusual in prescribing Utrogestan for such a short period as this can be more risky in terms of thickened endometrial lining. I think he does this so that women can avoid the symptoms of progesterone intolerance. The standard recommendation is that progesterone be taken for 12-14 days a month. This is to ensure that you have a proper bleed and all the endometrial lining is shed. If you take Utrogestan for only 7 days a month you will need to be closely monitored for thickening of your endometrial lining by having more frequent vaginal ultrasounds. Professor Studd usually advises women to start taking Utrogestan on the 1st day of the calendar month as this is the simplest procedure, so you could try that. You could try and work out your cycle based on the date of your last period or if you have already started taking the EstroGel, opt for any day. If you haven’t already started, start the EstroGel and count day one of EstroGel as day one of your cycle and then start the Utrogestan on day 12. I hope that helps.
The five observational studies and the Xu meta-analysis were discussed at a joint meeting of the Bone, Reproductive and Urologic Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee on September 17, 2014. Based on these findings, the advisory committee members were in general agreement that the signal of cardiovascular risk is weak and that only a prospective, well-controlled clinical trial could determine whether testosterone causes cardiovascular harm. The Corona study was recently published and could not be reviewed in time to be presented at the Advisory Committee meeting; however, we have reviewed the study and factored its findings into our overall assessment.
Almost all of the clinical trials studying TRT have been inconclusive or have not followed patients long-term, so this treatment option is still a bit experimental in practice, and the treatment should not be administered to anyone not deemed an exceptional candidate. Because of the serious nature of TRT, patients with less severe testosterone deficiencies may look into safer, alternative treatment options. Any man currently taking TRT needs to see their doctor regularly for checkups, and should report any medical issues immediately. In addition, prostate screenings are essential.
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