Radical scavenging activity was also measured in vitro by the tetrazolium nitroblue assay on a commercial juice, by assessing the potential capacity of the juice to protect cells or lipids from oxidative alteration promoted by superoxide anion radicals (SAR). The SAR scavenging activity of noni juice was times higher than that of vitamin C, times that of pycnogenol, and almost of the same order as that of grape seed powder. 1 New iridoid glucosides isolated from methanol extracts of noni fruits, neolignan, and americanin A were found to be potent antioxidants. 23
Antipsychotic drugs, including thiothixene (3) , elevate prolactin levels; the elevation persists during chronic administration. Tissue culture experiments indicate that approximately one-third of human breast cancers are prolactin dependent in vitro, a factor of potential importance if the prescription of these drugs is contemplated in a patient with a previously detected breast cancer. Although disturbances such as galactorrhea, amenorrhea, gynecomastia, and impotence have been reported, the clinical significance of elevated serum prolactin levels is unknown for most patients. An increase in mammary neoplasms has been found in rodents after chronic administration of antipsychotic drugs. Neither clinical studies nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis; the available evidence is considered too limited to be conclusive at this time.