In men, the decline of testosterone with age is gradual. But in women, testosterone declines precipitously at menopause. While the simultaneous disappearance of estrogen is more urgent for women, the loss of testosterone matters, since it often results in fatigue and the decline of sexual appetite . As a result, many postmenopausal women find themselves in the middle of a medical quandary: Should they risk taking a dollop or two of testosterone to regain some of their sexuality, sensuality, and vitality? The question is especially difficult to answer since it I depends in part on the infinitely variable physical and emotional characteristics of individual women. Some doctors do treat postmenopausal women with small, carefully-dosed amounts of testosterone and see renewed libido. But other doctors are hesitant about carrying hormone therapy quite this far, citing, such possible side effects as the growth of unwanted facial and body hair.
The partition coefficient of the ester in question is important because is effects how long the drug itself stays in the system. If the testosterone transfers too quickly from the oil to the blood, the result is a sudden spike in testosterone which then rapidly drops once the dose has been used up. In the example of free testosterone injected into the muscle from a water suspension (as in Aquiviron, mentioned above), the testosterone is essentially immediately available to the bloodstream due to its low partition coefficient, and thus there is an immediate spike of testosterone which is used up quickly in the body.