But I'm not more aggressive—a behavior change often tied to testosterone. That's not surprising to Robert Sapolsky, ., a neuroendocrinologist at Stanford University and a leading researcher on stress and behavior. "It's really not the case that testosterone 'causes' aggressive behavior," he says. "Instead, it makes the brain more sensitive to social cues that trigger aggression. And in support of that, a guy's testosterone level isn't a very good predictor of how likely he is to be aggressive."
Almost all of the clinical trials studying TRT have been inconclusive or have not followed patients long-term, so this treatment option is still a bit experimental in practice, and the treatment should not be administered to anyone not deemed an exceptional candidate. Because of the serious nature of TRT, patients with less severe testosterone deficiencies may look into safer, alternative treatment options. Any man currently taking TRT needs to see their doctor regularly for checkups, and should report any medical issues immediately. In addition, prostate screenings are essential.
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