Furthermore, pre-treatment total testosterone was an independent predictor of extraprostatic disease in patients with localized prostate cancer; as testosterone decreases, patients have an increased likelihood of non-organ confined disease and low serum testosterone levels are associated with positive surgical margins in radical retropubic prostatectomy. A clinical implication of these results concerns androgen supplementation which has become easier to administer with the advent of transdermal preparations (patch or gel) that achieve physiological testosterone serum levels without supra physiological escape levels. During the clinical development of a new testosterone patch in more than 200 primary or secondary hypogonadal patients, no prostate cancer was diagnosed.
For the majority of the 1990’s after the original Steroid Control Act, steroid news would begin to take a back seat; according to the “experts” anabolic steroids had been beaten and put in its rightful dead to rot place; they could not have been more wrong. Ironically, it would also be in the 1990’s when anabolic steroids began to see heavy use by the medical community to improve survival rates of AIDS and Cancer patients, when it was discovered that loss of lean body mass was associated with increased mortality rates respective to these diseases (14). With this discovery some, including the four governing bodies mentioned during the Steroid Control Act have asked one serious perplexing question; if anabolic steroids are bad for you and will kill you if you’re healthy, how is it they are good for you and will save your life if you are sick? Raise your hand if you have a good answer for that one.