Fluphenazine decanoate bnf

"It belongs to the piperazine class of phenothiazines and is extremely potent; more potent than haloperidol and around fifty to seventy times the potency of chlorpromazine."

While fluphenazine certainly is a highly potent neuroleptic, I don't think it's more potent than haloperidol. Most sources I have state, that the neuroleptic potency of fluphenazine dihydrochloride administred orally or intramusculary is somewhere between 30 and 40 (maximum 50) chlorpromazine-equivalents; haloperidol is stated to have CPZeq. of 50 in all sources I have to my disposition; thus, fluphenazine is slightly less, or maximaly equaly potent, compared to haloperidol; in one publication, intramuscular fluphenazine decanoate is stated to have a potency of about 115 - 130 CPZeq's, but then again, haloperidol decanoate . is stated to have potency of 110 - 125 CPZeq.-- 00:12, 1 May 2007 (UTC)

Decanoic acid acts as a non-competitive AMPA receptor antagonist at therapeutically relevant concentrations, in a voltage- and subunit-dependent manner, and this is sufficient to explain its antiseizure effects. [13] This direct inhibition of excitatory neurotransmission by decanoic acid in the brain contributes to the anticonvulsant effect of the MCT ketogenic diet . [13] Decanoic acid and the AMPA receptor antagonist drug perampanel act at separate sites on the AMPA receptor, and so it is possible that they have a cooperative effect at the AMPA receptor, suggesting that perampanel and the ketogenic diet could be synergistic. [13]

Fluphenazine came into use in 1959. [6] The injectable form is on the World Health Organization's List of Essential Medicines , the most effective and safe medicines needed in a health system . [7] It is available as a generic medication . [1] In the United States the tablets costs between and USD per day for a typical dose. [1] The wholesale cost in the developing world of the long acting form is between and USD per injection as of 2014. [8] It was discontinued in Australia around mid 2017. [9]

Fluphenazine decanoate bnf

fluphenazine decanoate bnf


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