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Response and effectiveness of Fioricet is excellent. Acetaminophen pain relieving effects will be attained within one hour of administration. Butalbital is absorbed properly in the gastrointestinal tract; the effects of sedating and muscle relaxing are evident two hours. Butalbital has high risk of interacting with other medications because metabolized by CYP450 enzyme, in the liver. It can take effect in the body for up to 35 hours which means a repeated intake may result to over use, hence escalating the side effects. Caffeine has a short life of between 3 to 7 hours and is metabolized in the liver.