Correlations between circulating DHEA/DHEAS levels and urticaria and other immune-related disorders has led to proposals for DHEA supplementation. However, clinical trials are largely lacking. 28 , 29 , 30 In 1 study, no effect of DHEA supplementation was found in well-established rheumatoid arthritis. 24 Decreased disease activity was observed in a study of patients with inflammatory bowel disease. However, the study was not placebo controlled. 24 Animal studies of experimental sepsis and trauma have shown DHEA to decrease splenocyte proliferation and increase circulating NK cells and CD8+ lymphocytes; a role in managing critical illness has been suggested as a result. 31
DHEA Dosing and Safety Precautions Information
The Life Extension Foundation has been investigating DHEA for more than 20 years. Life Extension's DHEA directions for use are specially drafted to provide optimal and side effects free safe dosing. A DHEA-S (dehydroepiandrosterone sulfate) blood test may be taken three to six weeks after initiating DHEA supplementation regimen to help determine optimal dosing. When having your blood tested for DHEA, blood should be drawn three to four hours after the last dose for the most benefits. DHEA testing may save you money if it shows that you can take less DHEA to maintain serum levels.