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DHEA is transformed into DHEA-S by sulfation at the C3β position via the sulfotransferase enzymes SULT2A1 and to a lesser extent SULT1E1 .    This occurs naturally in the adrenal cortex and during first-pass metabolism in the liver and intestines when exogenous DHEA is administered orally. [ citation needed ] Levels of DHEA-S in circulation are approximately 250 to 300 times those of DHEA.  DHEA-S in turn can be converted back into DHEA in peripheral tissues via steroid sulfatase (STS).  
We feel like 25 mg is a smart, conservative dosage: The minimum amount needed to restore DHEA to a younger state. Notably, some research shows that exercise helps maintain DHEA levels in older people, 10 which makes us wonder if these populations should just start an exercise routine instead of buying DHEA supplements. *Inside Scoop: About that Big Warning… Not all, but the best, most reputable supplement makers all have highly detailed, scary side effects listed on their DHEA products. They practically look like cigarette warnings. Why is this? It traces back to a decree by the State of California, which was probably motivated by DHEA controversies, including the NBA, NFL, and NCAA bans. Some feel the warning is ridiculous. Whether warranted or not, it definitely adds to DHEA’s reputation of potency and power. Here’s what it looks like: