There are also many drug interactions . Patients must read in detail the enclosed data sheet(s) of the medicine. For example, the azole antifungals such as ketoconazole or itraconazole can be both substrates and inhibitors of the P-glycoprotein , which (among other functions) excretes toxins and drugs into the intestines.  Azole antifungals also are both substrates and inhibitors of the cytochrome P450 family CYP3A4 ,  causing increased concentration when administering, for example, calcium channel blockers , immunosuppressants , chemotherapeutic drugs , benzodiazepines , tricyclic antidepressants , macrolides and SSRIs .
Frankly, making this antifungal spray couldn’t be easier, as you simply combine the ingredients into a 5-ounce or larger glass spray bottle and blend well. The key is getting these skin-healing ingredients, including aloe vera gel, apple cider vinegar and witch hazel . The latter includes tannins which make witch hazel extract a natural astringent, since they remove excess oil from skin. Apple cider vinegar, meanwhile, contains probiotics and a type of acid that promotes the growth of probiotics that can help kill off Candida.
It is used for the treatment of fungal infections, such as athlete's foot . It can have a slight burning effect that goes away after a few minutes. A systematic review of the medical literature examining all treatments for ringworm and jock itch was generally critical of the quality of data available. It concluded that there was "insufficient evidence to determine if Whitfield's ointment, a widely used agent is effective".  This means the studies executed were poor, not that Whitfield's ointment is necessarily ineffective. Individual studies, for instance "Treatment of superficial mycoses in the tropics: Whitfield's ointment versus clotrimazole"  support its use as a cost-effective treament.